Kroenke K, Theobald D, Wu J et al.
JAMA. 2010 Jul 14;304(2):163-71.
CONTEXT: Pain and depression are 2 of the most prevalent and treatable cancer-related symptoms, yet they frequently go unrecognized, undertreated, or both.
OBJECTIVE: To determine whether centralized telephone-based care management coupled with automated symptom monitoring can improve depression and pain in patients with cancer.
DESIGN, SETTING, AND PATIENTS: Randomized controlled trial conducted in 16 community-based urban and rural oncology practices involved in the Indiana Cancer Pain and Depression (INCPAD) trial. Recruitment occurred from March 2006 through August 2008 and follow-up concluded in August 2009. The participating patients had depression (Patient Health Questionnaire-9 score > or = 10), cancer-related pain (Brief Pain Inventory [BPI] worst pain score > or = 6), or both.