Scientific Perspectives

Animal Models in Pain Research
Jeffrey S. Mogil, PhD

Elucidation of the underpinnings of pain regulation in laboratory animals provides a powerful avenue for research into comparable mechanisms in humans.
Sodium Channel Expression in Keratinocytes: Implications for Neuropathic Pain
Frank L. Rice, PhD

Sodium channels are primary determinants of membrane excitability. Interestingly, recent evidence suggests that keratinocytes in the skin express voltage-gated sodium channels, with increased levels observed in such neuropathic pain conditions as complex regional pain syndrome type 1.
Pathophysiology of Acute Postoperative Pain
Timothy J. Brennan, MD, PhD

Postoperative incisional pain is a unique and common form of acute pain. Despite evidence for reduced morbidity and improved outcomes with effective postoperative pain management, pain remains under-treated after surgery.
Research Guideline to Expand the Evidence Base Supporting Long-Term Opioid Therapy for Chronic Noncancer Pain
Perry G. Fine, MD

The American Pain Society and American Academy of Pain Medicine have recently published guidelines to help clinicians appropriately position and prescribe opioids as a treatment option for chronic noncancer pain.

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Charles E. Argoff, MD

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Charles E. Argoff, MD

Features

Professor of Neurology
Albany Medical College
Director, Comprehensive Pain Center
Albany Medical Center
Albany, New York

Dennis D. Dykstra, MD, PhD

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Dennis D. Dykstra, MD, PhD

Associate Professor
Chairman
Department of Physical Medicine and Rehabilitation
University of Minnesota
Minneapolis, Minnesota

Biologic Drugs for Analgesia: Redefining the Opportunity

Hughes J, Hatcher JP, Chessell IP.
Curr Pharm Biotechnol. 2011 Apr 5.
Chronic pain...

Meng ID, Dodick D, Ossipov MH, Porreca F.
Cephalalgia. 2011 Mar 28.
Medication overuse...

Bruehl S.
Anesthesiology. 2010;113(3):713-25.
Complex regional pain syndrome (CRPS) is a...

Kim DH, Schwartz, CE.
Spine J. 2010;10(9):827-840.
BACKGROUND CONTEXT: Variability in...

Translational Pain Research: Achievements and Challenges.

Mao J.
J Pain. 2009;10(10):1001-11.
The achievements in both preclinical and clinical...