Scientific Perspectives :: Video Library

Video Library

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Target Identification Strategies in the Genomic Era
William R. Lariviere, PhD

Although the subjective nature of pain complicates reproducing and analyzing experiment pain in animal models, preclinical pain research has led to significant progress in clinical pain management.
Translational Pain Research: Achievements and Challenges
Jianren Mao, MD, PhD

Over the last few decades, significant achievements in pain research have led to improvements in clinical pain management.
Animal Models in Pain Research
Jeffrey S. Mogil, PhD

Elucidation of the underpinnings of pain regulation in laboratory animals provides a powerful avenue for research into comparable mechanisms in humans.
Sodium Channel Expression in Keratinocytes: Implications for Neuropathic Pain
Frank L. Rice, PhD

Sodium channels are primary determinants of membrane excitability. Interestingly, recent evidence suggests that keratinocytes in the skin express voltage-gated sodium channels, with increased levels observed in such neuropathic pain conditions...
Pathophysiology of Acute Postoperative Pain
Timothy J. Brennan, MD, PhD

Postoperative incisional pain is a unique and common form of acute pain. Despite evidence for reduced morbidity and improved outcomes with effective postoperative pain management, pain remains under-treated after surgery.
Research Guideline to Expand the Evidence Base Supporting Long-Term Opioid Therapy for Chronic Noncancer Pain
Perry G. Fine, MD

The American Pain Society and American Academy of Pain Medicine have recently published guidelines to help clinicians appropriately position and prescribe opioids as a treatment option for chronic noncancer pain.
Imaging of Clinical Pain
A. Vania Apkarian, PhD

Chronic pain has been defined as pain that persists longer than 3-6 months, and/or after resolution of the initial injury.
Do Past Pain Events Systematically Impact Pain Ratings of Healthy Subjects or Fibromyalgia Patients?
Roland Staud, MD, FACP, FACR

Some experts have suggested that although visual analogue pain ratings are generally reliable for a given individual, comparisons between subjects may be confounded by differences among individuals in past pain experiences.
Hippocampal correlates of pain in healthy elderly adults: A pilot study
Molly E. Zimmerman, PhD

Previous imaging studies of patients with chronic pain have identified abnormalities in the thalamus, prefrontal cortex, cingulate, and somatosensory cortex, each of which is involved in nociceptive processing.
Functional Imaging of CRPS
Sean C. Mackey, MD, PhD

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